Popular dietary supplements for treating joint pain may accelerate the development of dementia, study suggests

New research raises questions about the use of glucosamine

Millions of people use glucosamine supplements to manage joint pain and support mobility. However, new research suggests that this widely used supplement may be linked to faster cognitive decline in some individuals.

Researchers from the University of Florida examined the relationship between glucosamine use and the development of dementia. Their findings suggest that people with mild cognitive impairment (MCI) who took glucosamine regularly were more likely to develop Alzheimer’s disease than those who did not use the supplement.

The study examined thousands of patient records

To better understand the potential relationship, the researchers analyzed de-identified health records of patients diagnosed with Alzheimer’s disease and related dementia (ADRD) or mild cognitive impairment. The team used artificial intelligence tools to review patient data collected between 2012 and 2024.

The analysis revealed that approximately 8% of patients in both groups reported using glucosamine supplements. The researchers then investigated whether glucosamine use affected the development of cognitive decline.

The results indicate a faster progression of the disease

The results showed an association between glucosamine use and a greater likelihood of transitioning from mild cognitive impairment to Alzheimer’s disease. While the study did not prove a direct cause-and-effect relationship, it did identify an important relationship that requires further investigation.

According to MedicalXpress, the findings suggest that healthcare professionals and patients should carefully evaluate long-term use of glucosamine, especially among individuals who are already showing signs of cognitive impairment.

More research is needed

Although the study highlights a potential concern, the researchers stressed that the findings are observational. Therefore, they cannot prove that glucosamine directly causes faster progression of dementia.

Future clinical studies will be necessary to determine the underlying biological mechanisms and to confirm whether glucosamine plays a direct role in accelerating cognitive decline.

What patients should know

People who are currently taking glucosamine should not stop using the supplement without consulting their healthcare provider. Instead, they should discuss any concerns with a medical professional, especially if they have a family history of dementia or have already been diagnosed with mild cognitive impairment.

Until more evidence is available, experts recommend a cautious approach and encourage patients to make supplement decisions based on individual medical advice.